They are cells with healing potential that are taken from fat tissue or bone marrow and activated by special methods. They have the ability to regenerate and transform into other cells. It is used very frequently in orthopedic treatments. Joint calcification is one of the most important areas of use. It can be used in a patient who has knee pain and cartilage disorder in the knee joint and is significantly beneficial in relieving their complaints. It is removed from the patient's fat tissue via liposuction. Since no significant amount of fat is removed in orthopedic practices, no problems that may cause problems for patients develop in the area where fat is removed. The extracted fat tissue is prepared by passing it through special blades and applied to the problematic area. Stem cells to be taken from the bone marrow are prepared and applied by aspiration method. Today, it is one of the best methods used to relieve joint pain in patients who have not decided to have surgery, in patients who have been decided to have surgery but cannot be operated on, or in patients who do not want to have surgery. Our patients to whom we apply stem cells in our clinic have long-term follow-ups and we see very good results.